OLANZAPINA > VALPROAT in MANIE

  • Novick D et al. - The EMBLEM results support those of the RCT, which suggest that olanzapine monotherapy seems to be more effective than valproate monotherapy in the treatment of acute mania.
Methods
  • EMBLEM (European Mania in Bipolar Evaluation of Medication) was a 2-year, prospective, observational study of health outcomes associated with the treatment of mania.
  • Severity of mania and depression were assessed at baseline and 6 weeks using the YMRS and the 5-item version of the HAMD, respectively.
Results
  • 621 patients were analysed (n=107 valproate, n=514 olanzapine).
  • Both groups improved from baseline to 6 weeks in mean YMRS and HAMD-5 total scores, with greater mean improvements in the olanzapine compared with the valproate group.
  • Olanzapine was associated with more weight gain and less gastrointestinal difficulties than valproate.

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