Gross AL et al. - Results reveal a specificity to the association between depression and hormonally mediated cancers, which provides support to hypotheses about a common biological pathway
between depression and cancer. Methods
- Population-based sample of 3,177 cancer-free adults from Baltimore Epidemiologic Catchment Area Study followed for 24 years.
- Cox proportional hazards models used to estimate relative hazards for both overall and subtype-specific cancers among those with history of depression
Results
- Risk set contained 334 incident cancer cases and 40,530 person-years of observation
- DIS/DSM-III major depression associated with higher hazard for overall cancer (HR: 1.9, 95% CI: 1.2, 3.0) and statistically significant increased hazard for breast cancer (HR: 4.4,
95% CI: 1.08, 17.6) among women
- Positive association between history of depression and prostate cancer
- Confidence bounds included null
- No reliable associations found between colon, lung, or skin cancers and depression
- Pattern of results similar for dysphoria, but not for phobia or other mental disorders studied
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