MDLinx - New Articles

Your Article Summary Divalproex extended-release in acute bipolar II depression (>> click to go to the journal's website) Journal of Affective Disorders, 06/02/10

Wang PW et al. – Divalproex–ER as monotherapy and adjunctive therapy was well tolerated and yielded an overall response rate of 54% in bipolar II depression. Based on the results of this pilot study, randomized, double–blind, placebo–controlled studies of divalproex–ER in bipolar II depression are warranted. Receive more summaries like this by joining MDLinx. We provide free daily digests of top journal articles in your field. >> Click here to choose your specialties.

Other articles in Psychiatry >> Click here to see the complete list Genetic and environmental influences on focal brain density in bipolar disorder Brain, 09/29/10 Bipolar disorder and metabolic syndrome: An international perspective Journal of Affective Disorders, 10/07/10 Impairment of verbal learning and memory and executive function in unaffected siblings of probands with bipolar disorder Bipolar Disorders, 10/01/

 

 

Your Article Summary Hyperprolactinemia associated with psychotropics - a review (>> click to go to the journal's website) Human Psychopharmacology: Clinical and Experimental, 05/10/10

Madhusoodanan S et al. – Clinicians need to be alert about the potential for hyperprolactinemia and its manifestations with these medications. Prolactin levels need to be monitored and other causes of hyperprolactinemia ruled out in suspected cases. Receive more summaries like this by joining MDLinx. We provide free daily digests of top journal articles in your field. >> Click here to choose your specialties.

Other articles in Psychiatry >> Click here to see the complete list Risperidone-Induced Bulbar Palsy-like Syndrome Dysphagia, 10/26/10 Galactorrhea After Aesthetic Breast Augmentation With Silicone Implants: Report of Two Cases and Management of Postoperative Galactorrhea Aesthetic Plastic Surgery, 10/11/10 High levels of serum prolactin protect against diabetic retinopathy by increasing ocular vasoinhibins Diabetes, 09/13/10

Questionable Antipsychotic Prescribing Remains Common, Despite Serious Risks (>> click to go to the journal's website) JAMA, 04/28/10

Kuehn BM – Despite their association with serious cardiac and metabolic risks, atypical antipsychotics are widely used off–label with few data to support their efficacy, according to recent studies probing use of this class of drugs in the United States. Furthermore, physicians often do not follow through on precautions to reduce these risks. Receive more summaries like this by joining MDLinx. We provide free daily digests of top journal articles in your field. >> Click here to choose your specialties.

Other articles in Psychiatry >> Click here to see the complete list Treatment with antipsychotics and the risk of diabetes in clinical practice British Journal of Psychiatry, 10/06/10 Risk of Falls and Fractures in Older Adults Using Antipsychotic Agents: A Propensity-Matched Retrospective Cohort Study Drugs & Aging, 10/14/10 Predictors of switching antipsychotic medications in the treatment of schizophrenia BMC Psychiatry, 10/06/10

 

Your Article Summary The Role of Ondansetron in the Treatment of Schizophrenia (>> click to go to the journal's website) Annals of Pharmacotherapy, 06/04/10

Bennett AC et al. – Ondansetron may be effective as an adjunct to antipsychotics for the treatment of schizophrenia, specifically negative symptoms, as assessed with PANSS. Due to the variation in concurrent therapies and dosing regimens, it is difficult to establish an optimal dose from the reviewed trials. Further large, randomized, double–blind, active–controlled studies would be helpful in determining the role of ondansetron in the treatment of schizophrenia. Receive more summaries like this by joining MDLinx. We provide free daily digests of top journal articles in your field. >> Click here to choose your specialties.

Other articles in Psychiatry >> Click here to see the complete list Examining the course and outcome of individuals diagnosed with schizophrenia and comorbid borderline personality disorder Schizophrenia Research, 10/07/10 Analysis of HapMap tag-SNPs in dysbindin (DTNBP1) reveals evidence of consistent association with schizophrenia European Psychiatry , 10/07/10 Suicidal attempts and increased right amygdala volume in schizophrenia Schizophrenia Research, 10/07/10

 

Your Article Summary Treatment with antipsychotics and the risk of diabetes in clinical practice (>> click to go to the journal's website) British Journal of Psychiatry, 10/06/10

Kessing LV et al. ? The objective of this study was to investigate and characterise the incidence of diabetes for people treated with antipsychotic medication in clinical practice. In clinical practice, treatment with first- and second-generation antipsychotics is associated with an increased risk of developing incident diabetes with large differences between individual drugs. The risk increases with the duration of treatment and with polypharmacy of antipsychotic drugs. Methods Used linkage of registers of all prescribed antipsychotics, antidiabetics and diagnoses of diabetes in Denmark during period from 1996 to 2005 and identified all people treated with antipsychotics in Denmark and random sample of about 30% of total Danish population Results 345,937 patients who purchased antipsychotics and 1,426,488 unexposed individuals included 50,379 individuals subsequently developed incident diabetes Compared with unexposed individuals, treatment with first- (rate ratio, RR = 1.53, 95% CI 1.49?1.56) as well as second-generation (RR = 1.32, 95% CI 1.22?1.42) antipsychotics associated with increased risk of subsequent incident diabetes Rate of incident diabetes varied substantially between individual second-generation antipsychotic drugs (olanzapine, risperidone clozapine compared with unexposed individuals: low to moderate rate ratio between 1.17 and 1.57; ziprasidone and sertindol: 2 or more times increased rate ratio; amisulpride, quetiapine and aripiprazole: no significantly increased rate ratio) For both first- and second-generation antipsychotics, incidence of diabetes increased with number of prescriptions Incidence of diabetes increased with number of combined antipsychotic drugs Receive more summaries like this by joining MDLinx. We provide free daily digests of top journal articles in your field. >> Click here to choose your specialties.

Other articles in Psychiatry >> Click here to see the complete list Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in model behavioral models of anxiolytic and antipsychotic activity Molecular Pharmacology, 10/14/10 Psychotropic medication use mediates the relationship between mood and anxiety disorders and obesity: Findings from a nationally representative sample Journal of Psychiatric Research, 11/05/10 Risk of Hospitalization for Stroke Associated with Antipsychotic Use in the Elderly: A Self-Controlled Case Series Drugs & Aging, 11/05/10