Articole noi de la MedLinx

1.Your Article Summary Second-Generation Antipsychotic Drugs and Extrapyramidal Side Effects: A Systematic Review and Meta-analysis of Head-to-Head Comparisons Schizophrenia Bulletin, 09/10/10 Rummel–Kluge C et al. – These meta–analysis demonstrates that there are differences between the SGAs in their ability to induce EPS that clinicians consider warrant treatment with antimuscarinic drugs. Even though the differences were relatively small, they might be important for individual patients and should be taken into account in drug choice. Other articles in Psychiatry >> Click here to see the complete list Associated factors with antipsychotic use in assisted living facilities: a cross-sectional study of 4367 residents Age and Aging, 03/24/11 Treatment Strategies for Dosing the Second Generation Antipsychotics CNS Neuroscience & Therapeutics, 03/18/11 Early response to antipsychotic therapy as a clinical marker of subsequent response in the treatment of patients with first-episode psychosis Psychiatry Research, 04/05/11

2.Your Article Summary Presynaptic Dopamine in Schizophrenia CNS Neuroscience & Therapeutics, 01/11/11 Miyake N et al. – Excessive striatal presynaptic dopamine is linked to the emergence of acute psychotic symptoms and to their response to treatment in schizophrenia. Understanding the etiology of this dysregulation and its consequences on the rest of the circuitry is important for future drug development.. Other articles in Psychiatry >> Click here to see the complete list Common variants in the BCL9 gene conferring risk of schizophrenia Archives of General Psychiatry, 03/14/11 Evidence for an emotion maintenance deficit in schizophrenia Psychiatry Research, 04/13/11 Sleep?wake cycles and cognitive functioning in schizophrenia British Journal of Psychiatry, 04/11/11

3.Your Article Summary The relationship between cognitive insight, clinical insight, and depression in patients with schizophrenia Comprehensive Psychiatry, 04/27/11 Ugurlu GK et al. – A better understanding of the cognitive component of insight in schizophrenia with comorbid depression may contribute to develop more efficient cognitive strategies, thus improving patient outcome. However, clinicians should be aware of the possibility of exacerbating a sense of hopelessness and suicide risk during the interventions that improve cognitive insight. Other articles in Psychiatry >> Click here to see the complete list The incidence and relative risk factors for developing cancer among patients with schizophrenia: A nine-year follow-up study Schizophrenia Research, 04/21/11 Analysis of 94 Candidate Genes and 12 Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia American Journal of Psychiatry, 04/25/11 Association of Schizophrenia in 22q11.2 Deletion Syndrome and Gray Matter Volumetric Deficits in the Superior Temporal Gyrus American Journal of Psychiatry, 04/25/11

4.Your Article Summary Cognitive-Behavioral Therapy for Medication-Resistant Schizophrenia: A Review FOCUS (The Journal of Lifelong Learning in Psychiatry), 01/14/11 Rathod S et al. – Research meta–analyses have found that cognitive–behavioral therapy (CBT) is beneficial for persistent symptoms of schizophrenia. This review describes and updates the evidence base for this statement. Other articles in Psychiatry >> Click here to see the complete list Common variants in the BCL9 gene conferring risk of schizophrenia Archives of General Psychiatry, 03/14/11 Evidence for an emotion maintenance deficit in schizophrenia Psychiatry Research, 04/13/11 Sleep?wake cycles and cognitive functioning in schizophrenia British Journal of Psychiatry, 04/11/11

5.Your Article Summary Spirituality and religiousness as predictive factors of outcome in schizophrenia and schizo-affective disorders Psychiatry Research, 03/24/11 Mohr S et al. – Spirituality and religiousness have been shown to be highly prevalent in patients with schizophrenia. These study shows that helpful use of spirituality is predictive of a better outcome. Spirituality may facilitate recovery by providing resources for coping with symptoms. In some cases, however, spirituality and religiousness are a source of suffering. Helpful vs. harmful spiritual/religious coping appears to be of clinical significance. Other articles in Psychiatry >> Click here to see the complete list The incidence and relative risk factors for developing cancer among patients with schizophrenia: A nine-year follow-up study Schizophrenia Research, 04/21/11 Association of Schizophrenia in 22q11.2 Deletion Syndrome and Gray Matter Volumetric Deficits in the Superior Temporal Gyrus American Journal of Psychiatry, 04/22/11 Characteristics and predictors of long-term institutionalization in patients with schizophrenia Schizophrenia Research, 04/20/11

6.Your Article Summary Angiotensin receptor blockers and risk of myocardial infarction: meta-analyses and trial sequential analyses of 147 020 patients from randomised trials British Medical Journal, 05/06/11 Bangalore S et al. – This large and comprehensive analysis produced firm evidence to refute the hypothesis that angiotensin receptor blockers increase the risk of myocardial infarction (ruling out even a 0.3% absolute increase). Compared with controls, angiotensin receptor blockers reduce the risk of stroke, heart failure, and new onset diabetes. Methods Systematic review of randomised controlled trials with meta–analysis and trial sequential analysis (TSA). Pubmed, Embase, and CENTRAL searches for randomised clinical trials, until August 2010, of angiotensin receptor blockers compared with controls (placebo/active treatment) that enrolled at least 100 participants and had a follow–up of at least one year. 37 randomised clinical trials included 147 020 participants and had a total follow–up of 485 166 patient years. Results When compared with controls (placebo/active treatment), placebo, or active treatment, angiotensin receptor blockers were not associated with an increase in the risk of myocardial infarction (relative risk 0.99, 95% confidence interval 0.92 to 1.07), death, cardiovascular death, or angina pectoris. Compared with controls, angiotensin receptor blockers were associated with a reduction in the risk of stroke (0.90, 0.84 to 0.98), heart failure (0.87, 0.81 to 0.93), and new onset diabetes (0.85, 0.78 to 0.93), with similar results when compared with placebo or with active treatment. Based on trial sequential analysis, there is no evidence even for an average 5.0–7.5% (upper confidence interval 5–11%) relative increase in myocardial infarction (absolute increase of 0.3%), death, or cardiovascular death with firm evidence for relative risk reduction of stroke (at least 1%, average 10%) (compared with placebo only), heart failure (at least 5%, average 10%), and new onset diabetes (at least 4%, average 10%) with angiotensin receptor blockers compared with controls. Other articles in Internal Medicine >> Click here to see the complete list Frequency and Predictors of Stent Thrombosis After Percutaneous Coronary Intervention in Acute Myocardial Infarction Circulation, 04/12/11 B-type Natriuretic Peptide in the Early Diagnosis and Risk Stratification of Acute Chest Pain American Journal of Medicine, 05/02/11 A New Therapeutic Strategy for Acute Ischemic Stroke Stroke, 04/29/11

7.Your Article Summary Second-generation antipsychotics and constipation: A review of the literature European Psychiatry , 01/30/11 De Hert M et al. – Antipsychotics are the cornerstone in the management of psychotic disorders and schizophrenia. They are effective agents but also have a wide range of side effects. In the recent literature constipation as possible side effect has received little attention. A review of the literature concerning constipation associated with antipsychotics was performed. Overall constipation is a rarely studied or reported side effect of antipsychotic medication. Nevertheless constipation is a common side effect. Other articles in Psychiatry >> Click here to see the complete list Lubiprostone for the Treatment of Adults with Constipation and Irritable Bowel Syndrome Digestive Diseases and Sciences, 05/02/11 Development of quality indicators based on a multidisciplinary, evidence-based guideline on pediatric constipation European Journal of Pediatrics, 04/18/11 Stapled Transanal Rectal Resection (STARR) and Sacral Nerve Stimulation (SNS)- Impact on faecal incontinence and quality of life Colorectal Disease, 04/18/11

8.Your Article Summary Neuroanatomical Abnormalities That Predate the Onset of Psychosis: A Multicenter Study Archives of General Psychiatry, 05/11/11 De Hert M et al. – Antipsychotics are the cornerstone in the management of psychotic disorders and schizophrenia. They are effective agents but also have a wide range of side effects. In the recent literature constipation as possible side effect has received little attention. A review of the literature concerning constipation associated with antipsychotics was performed. Overall constipation is a rarely studied or reported side effect of antipsychotic medication. Nevertheless constipation is a common side effect. Other articles in Psychiatry >> Click here to see the complete list Lubiprostone for the Treatment of Adults with Constipation and Irritable Bowel Syndrome Digestive Diseases and Sciences, 05/02/11 Development of quality indicators based on a multidisciplinary, evidence-based guideline on pediatric constipation European Journal of Pediatrics, 04/18/11 Stapled Transanal Rectal Resection (STARR) and Sacral Nerve Stimulation (SNS)- Impact on faecal incontinence and quality of life Colorectal Disease, 04/18/11

9.Your Article Summary Cognitive function and competitive employment in schizophrenia: Relative contribution of insight and psychopathology Social Psychiatry and Psychiatric Epidemiology, 04/07/11

Giugiario M et al. ? Taken together, these findings confirmed the importance of cognitive function in obtaining competitive employment. These results also highlighted the independent role of general psychopathology and awareness of illness on occupational functioning in schizophrenia. A greater attention must be given to the systematic investigation of insight and general psychopathology in light of an amelioration of vocational functioning in stable schizophrenia. Methods Recruited 253 outpatients with stable schizophrenia and further divided sample into 2 groups of patients (unemployed and competitive employment subjects) Clinical and neuropsychological assessments performed All clinical variables significantly different between 2 groups of subjects subsequently analyzed using binary logistic regression Assessed independent contribution to competitive employment in 2 patients? groups On basis of regression results 2 mediation analyses performed Results Verbal memory, general psychopathology, and awareness of mental illness significantly associated with competitive employment Awareness of mental illness and general psychopathology had role in mediating verbal memory?competitive employment relationship

Other articles in Psychiatry >> Click here to see the complete list Psychopathology, coronary heart disease and metabolic syndrome in schizophrenia spectrum patients with deficit versus non-deficit schizophrenia: Findings from the CLAMORS study European Neuropsychopharmacology, 04/12/11 Schizoaffective disorder-an ongoing challenge for psychiatric nosology European Psychiatry , 05/06/11 Testing the Psychosis Continuum: Differential Impact of Genetic and Nongenetic Risk Factors and Comorbid Psychopathology Across the Entire Spectrum of Psychosis Schizophrenia Bulletin, 05/05/11