nou in depresii

Vilazodone: In Major Depressive Disorder
CNS Drugs, 07/31/2011  Clinical Article

Frampton JE – Vilazodone was generally well tolerated in the short– and long–term treatment of major depressive disorder (MDD), with diarrhoea and nausea being the most frequently occurring treatment–emergent adverse events. Vilazodone had a minimal impact on sexual functioning in the three phase III studies.

    Vilazodone, a novel antidepressant agent that combines selective serotonin reuptake inhibitor (SSRI) activity and serotonin 5–HT1A receptor partial agonist activity in a single molecule, is indicated for the treatment of major depressive disorder (MDD) in the US.
    It is administered orally, once daily, with food.
    At the recommended dosage of 40 mg/day, vilazodone was effective in the short–term treatment of MDD in adults, as evidenced by significant improvements versus placebo on multiple measures of depression, including the Montgomery–Åsberg Depression Rating Scale (MADRS) and the 17–item Hamilton Rating Scale for Depression (HAM–D–17), in two pivotal, 8–week, randomized, double–blind, phase III studies.
    Significant differences between vilazodone and placebo on the MADRS and HAM–D–17 were seen after 1 week of treatment (first efficacy timepoint) in one of the two studies.
    Long–term treatment with vilazodone 40 mg/day was associated with an improvement from baseline in depressive symptoms in a 52–week, noncompar–ative, phase III study

A S P I R I N A

July 20, 2011 (Madrid, Spain) — A new study has confirmed the importance of continuing to take aspirin long term for patients with a history of heart disease [1].

The study, published online in the British Medical Journal on July 19, 2011, found that patients who stop taking aspirin are at a significantly increased risk of MI than those who continue treatment.

P R O B L E M A

Normalul ignora psihicul,este neproblematic.

Problema apare odata cu dezechilibrul normalitatii,cu psihopatologia.

A L Z H E I M E R

I study falls in older adults, and we know that the fall rate among older adults who have Alzheimer's disease is much higher than in adults who do not," Dr. Stark said.

Editorial Iulie 2011 - Profesor Dr. Aurel ROMILA


N E R V I



     Toata lumea foloseste cuvintul cand spune "l-au lasat nervii" sau" are nervii tari".
     Nervii sunt un sinonim de psihic, dar si de curaj, moral, personaliatate.
     Important de stiut este ca acest cuvint nu acopera totul ci este doar baza constructiei. Aceasta structura a fost intuita de Frankl si Laengle. Puterea psihologica este dedesubt, este in culisele persoanei, nu se  vede ci se deduce din actiune.
Are participare la fiecare moment, dar si la cursa intrega a existentei. Este diferentiala care face diferenta intre doi intr-o competitie. Chiar daca ei par egali ca inteligenta, dar de fapt sunt inegali ca vointa. N-A VAZUT SCHOPENHAUER PERSOANA CA VOINTA SI REPREZENTARE IAR NIETZSCHE CA VOINTA DE PUTERE?
     Decisiv este inconstientul, ca forta dinamica ,ca izvor energetic, care da un SINE puternic. Dar nervii trebuiesc controlati de ego, alttfel omul e nervos. Isi pierde capul, controlul si face o prostie, o impulsiune pe care apoi poate sa o regrete, dar greseala s-a produs.
      Ciudat, dar medic de nervi nu e neurologul ci psihiatrul! El este antrenorul, couchul si tonicul pentru nervi. Exista nervi, asa ca exista si psihiatri !

Profesor Dr. Aurel ROMILA

Medlinks news July

Your Article Summary

Association between atherosclerosis and osteoporosis, the role of vitamin D
Archives of Medical Science, 05/31/11
Stojanovic OI et al. – The latest data support the correlation of atherosclerosis and osteoporosis, indicating the parallel progression of two tissue destruction processes with increased fatal and non–fatal coronary events, as well as higher fracture risk.
  • Vitamin D inadequacy associated with low bone mineral density increases fall and fracture risk, leads to secondary hyperparathyroidism, calcifies coronary arteries and significantly increases cardiovascular disease.
  • Randomized clinical trial evidence related to extraskeletal vitamin D outcomes was limited and generally uninformative.
  • A recent recommendation on vitamin D dietary requirements for bone health is 600 IU/d for ages 1–70 years and 800 IU/d for 71 years and older, corresponding to a serum 25–hydroxyvitamin D level of at least 20 ng/ml (50 nmol/l)
  • Further large randomized controlled trials are needed to reassess laboratory ranges for 25–hydroxyvitamin D in both diseases, in order to avoid under– and over–treatment problems, and completely clarify the relationship between atherosclerosis and osteoporosis.

Other articles in Internal Medicine

>> Click here to see the complete list

Stroke Risk After Coronary Artery Bypass Graft Surgery and Extent of Cerebral Artery Atherosclerosis
JACC - Journal of the American College of Cardiology, 04/26/11

Association Between Obesity, High-Sensitivity C-Reactive Protein 2 mg/L, and Subclinical Atherosclerosis
Arteriosclerosis, Thrombosis, and Vascular Biology, 05/04/11

Tc-99m sestamibi lower extremity muscle scan, is it a useful screening tool for assessment of preclinical atherosclerosis in rheumatoid arthritis patients?
Rheumatology International, 04/21/11

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Your Article Summary

Effect of Aspirin on Mortality in the Primary Prevention of Cardiovascular Disease
American Journal of Medicine, 06/21/11
Raju N et al. – Aspirin prevents deaths, myocardial infarction, and ischemic stroke, and increases hemorrhagic stroke and major bleeding when used in the primary prevention of cardiovascular disease. Methods
  • Eligible articles were identified by searches of electronic databases and reference lists.
  • Outcomes of interest were all–cause mortality, cardiovascular mortality, myocardial infarction, stroke, and bleeding.
  • Data were pooled from individual trials using the DerSimonian–Laird random–effects model, and results are presented as relative risk (RR) and 95% confidence intervals (CIs).
Results
  • Nine randomized controlled trials enrolling 100,076 participants were included.
  • Aspirin reduced all–cause mortality (RR 0.94; 95% CI, 0.88–1.00), myocardial infarction (RR 0.83; 95% CI, 0.69–1.00), ischemic stroke (RR 0.86; 95% CI, 0.75–0.98), and the composite of myocardial infarction, stroke, or cardiovascular death (RR 0.88; 95% CI, 0.83–0.94), but did not reduce cardiovascular mortality (RR 0.96; 95% CI, 0.84–1.09).
  • Aspirin increased the risk of hemorrhagic stroke (RR 1.36; 95% CI, 1.01–1.82), major bleeding (RR 1.66; 95% CI, 1.41–1.95), and gastrointestinal bleeding (RR 1.37; 95% CI, 1.15–1.62).
  • A lack of availability of patient–level data precluded exploration of benefits and risks of aspirin in key subgroups.

Other articles in Internal Medicine

>> Click here to see the complete list

The Role of Aspirin in Childhood Tuberculous Meningitis
Journal of Child Neurology, 06/16/11

Effect of Aspirin Dose on Mortality and Cardiovascular Events in People with Diabetes: A Meta-Analysis
Journal of General Internal Medicine, 06/10/11

Meta-Analysis of Multiple Primary Prevention Trials of Cardiovascular Events Using Aspirin
The American Journal of Cardiology, 06/09/11

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Medscape articole noi Iulie

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