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MIRCEA ELIADE - OPERA on line
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Redactia: Profesor Dr. Aurel Romila (Presedinte APLR), Psih. Paula Anghelita; Adresa revistei este: http://www.aplr-doctorat.blogspot.com
http://indhyana.blogspot.com/2011/12/razboiul-parapsihologic-documentar.html
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The Year in Neurology: Studies Not to
Miss From 2011 |
| Most Emailed Articles on Medscape | |
| 1. | A Matter of Respect and Dignity: Bullying in the Nursing Profession Medscape Nurses |
| 2. | Vitamin D Supplementation: An Update US Pharmacist |
| 3. | Overhauling Nursing Education Medscape Nurses |
| 4. | The 2010 AHA Guidelines: The 4 Cs of Cardiac Arrest Care Medscape Emergency Medicine |
| 5. | The Downward Spiral: Incivility in Nursing Medscape Nurses |
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APA Answers DSM-5
Critics |
| Most Emailed Articles on Medscape | |
| 1. | A Matter of Respect and Dignity: Bullying in the Nursing Profession Medscape Nurses |
| 2. | Vitamin D Supplementation: An Update US Pharmacist |
| 3. | Overhauling Nursing Education Medscape Nurses |
| 4. | The 2010 AHA Guidelines: The 4 Cs of Cardiac Arrest Care Medscape Emergency Medicine |
| 5. | The Downward Spiral: Incivility in Nursing Medscape Nurses |
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Petition Calls for Critical Changes to
Upcoming DSM-5 |
| Most Emailed Articles on Medscape | |
| 1. | A Matter of Respect and Dignity: Bullying in the Nursing Profession Medscape Nurses |
| 2. | Vitamin D Supplementation: An Update US Pharmacist |
| 3. | Overhauling Nursing Education Medscape Nurses |
| 4. | The 2010 AHA Guidelines: The 4 Cs of Cardiac Arrest Care Medscape Emergency Medicine |
| 5. | The Downward Spiral: Incivility in Nursing Medscape Nurses |
Role of bisphosphonates in the management of postmenopausal
osteoporosis: an update on recent safety anxieties |
| Hollick RJ et al. – This review summarizes the benefits and potential adverse effects of bisphosphonates used in the treatment of postmenopausal osteoporosis. Although evidence of a definitive casual relationship between bisphosphonate therapy and serious adverse effects is lacking, concern remains particularly in relation to atypical subtrochanteric and femoral shaft fractures. This has important consequences in terms of determining optimum duration of therapy and how best to target therapy at those most at risk. Recently, attention has focused on individual fracture risk assessment in order to optimize the risk?benefit ratio of treatment for individual patients. A review of the role of hormone replacement therapy in younger women with significant risk of osteoporotic fractures may be timely in these circumstances. |
Serotonin, dopamine and addiction
Lower levels of brain 5-hydroxytryptamine (5-HT) have been associated with impulsive and aggressive traits, which in turn are related to increased levels of stimulant misuse. Cox et al (pp. 391–397) used neurochemical imaging to demonstrate that lowering 5-HT levels leads to an increase in cocaine-induced craving and striatal dopaminergic response, a possible mechanism for increased drug-seeking behaviour. In an accompanying editorial, Nutt (pp. 353–354) questions the clinical implications of this finding, commenting on the lack of effect of selective serotonin reuptake inhibitors as anti-addiction agents. He also raises the questions of whether 5-HT may also modulate other neurotransmitters and influence the use of other drugs, and whether one should also examine the role of well-established genetic variation in 5-HT reuptake sites.
Early treatment of schizophrenia and related psychotic disorders is likely to minimize the risk for complications of untreated psychosis, including dangerous behaviors and functional impairments. Intervention soon after the onset of illness may increase the likelihood of recovery. Choice of antipsychotic agent should be based on the response of the individual patient to the medication trial, including efficacy and tolerability. It is important to remember that negative symptoms may be secondary to the use of an antipsychotic agent, and these secondary negative symptoms may impede functional recovery. Remission should be expected, but once remission from the first episode is reached, the clinician and patient face the difficult issue of maintenance treatment duration. Despite remission, relapse risk is very high, especially if antipsychotic medication is discontinued. Clinically useful predictors of the small minority who maintain in remission without pharmacotherapy have not yet been identified, and the optimal length of maintenance treatment for recovered patients is not known. Prevention of recurrent relapse may reduce the risk for clinical deterioration and the development of chronic and disabling symptoms.
Mifepristone reduces relapse in alcoholics
Based on a rodent model, researchers at UCSF have reported in Neuropsychopharmacology that the pregnancy termination agent, mifepristone (RU-486) can reduce relapse in alcoholics. Mifepristone blocks the activity of progesterone and cortisol, which are known to promote alcoholism and relapse. In the study, the rats were trained to press a lever for alcohol or sucrose solutions. After a period of abstinence, the rats were "stressed" by administering yohimbine. Rats that received mifepristone prior to yohimbine sought the alcohol solution less frequently than rats that received yohimbine alone
Super-refractory status epilepticus is a serious condition. The mortality rate is substantial, reported in various series between 30 and 50%. Yet, despite the fact that it remains an important clinical problem in all neurology centres worldwide, for many therapies, and treatment approaches, there is a remarkable lack of published data concerning effectiveness, safety or outcome. Treatment protocols, therefore, are needed and in Fig. 2, a general approach to treatment is proposed, based on the clinical experience and the published literature. Doses and parameters of treatment are shown in Table 2 and Table 3.
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