Clinical Importance of Sleep Disturbance as a Treatment
Target in PTSD
FOCUS (The Journal of Lifelong Learning in Psychiatry), 05/13/09
Lydiard RB et al. - Examination of efficacy studies of the first-line treatments for posttraumatic stress disorder (PTSD)-selective serotonin reuptake inhibitors and cognitive behavior therapy-indicates that neither adequately treats PTSD nightmares and insomnia. Based on clinical reports, imaging, and polysomnographic studies, a theoretical model in which REM dysregulation in PTSD plays a key role in the development and persistence of PTSD will be presented. Finally, evidence regarding the beneficial effects of prazosin and other agents in the treatment of PTSD-related sleep disturbance will be highlighted.
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