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Olanzapine Dependence (>> click to go to the journal's website)
German Journal of Psychiatry, 04/14/10

Dhar R et al. – Olanzapine is the second–generation antipsychotic most frequently prescribed for treatment of schizophrenia and bipolar affective disorder. Its side effects include sedation, weight gain, hyperglycemia and hyperlipidemia. It is considered to be devoid of any abuse or dependence potential. Receive more summaries like this by joining MDLinx. We provide free daily digests of top journal articles in your field. >> Click here to choose your specialties.

Other articles in Psychiatry >> Click here to see the complete list Asenapine for long-term treatment of bipolar disorder: A double-blind 40-week extension study Journal of Affective Disorders, 10/07/10 Visceral and Subcutaneous Fat in Patients Treated With Olanzapine: A Case Series Clinical Neuropharmacology, 10/05/10 An exploratory analysis of factors associated with weight change in a 16-week trial of oral vs. orally disintegrating olanzapine: the PLATYPUS study International Journal of Clinical Practice, 10/01/10

 

 

 

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Questionable Antipsychotic Prescribing Remains Common, Despite Serious Risks (>> click to go to the journal's website)
JAMA, 04/28/10

Kuehn BM – Despite their association with serious cardiac and metabolic risks, atypical antipsychotics are widely used off–label with few data to support their efficacy, according to recent studies probing use of this class of drugs in the United States. Furthermore, physicians often do not follow through on precautions to reduce these risks. Receive more summaries like this by joining MDLinx. We provide free daily digests of top journal articles in your field. >> Click here to choose your specialties.

Other articles in Psychiatry >> Click here to see the complete list Treatment with antipsychotics and the risk of diabetes in clinical practice British Journal of Psychiatry, 10/06/10 Risk of Falls and Fractures in Older Adults Using Antipsychotic Agents: A Propensity-Matched Retrospective Cohort Study Drugs & Aging, 10/14/10 Predictors of switching antipsychotic medications in the treatment of schizophrenia BMC Psychiatry, 10/06/10

 

 

 

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Hyperprolactinemia associated with psychotropics - a review (>> click to go to the journal's website)
Human Psychopharmacology: Clinical and Experimental, 05/10/10

Madhusoodanan S et al. – Clinicians need to be alert about the potential for hyperprolactinemia and its manifestations with these medications. Prolactin levels need to be monitored and other causes of hyperprolactinemia ruled out in suspected cases. Receive more summaries like this by joining MDLinx. We provide free daily digests of top journal articles in your field. >> Click here to choose your specialties.

Other articles in Psychiatry >> Click here to see the complete list Risperidone-Induced Bulbar Palsy-like Syndrome Dysphagia, 10/26/10 Galactorrhea After Aesthetic Breast Augmentation With Silicone Implants: Report of Two Cases and Management of Postoperative Galactorrhea Aesthetic Plastic Surgery, 10/11/10 High levels of serum prolactin protect against diabetic retinopathy by increasing ocular vasoinhibins Diabetes, 09/13/10

 

 

 

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Divalproex extended-release in acute bipolar II depression (>> click to go to the journal's website)
Journal of Affective Disorders, 06/02/10

Wang PW et al. – Divalproex–ER as monotherapy and adjunctive therapy was well tolerated and yielded an overall response rate of 54% in bipolar II depression. Based on the results of this pilot study, randomized, double–blind, placebo–controlled studies of divalproex–ER in bipolar II depression are warranted. Receive more summaries like this by joining MDLinx. We provide free daily digests of top journal articles in your field. >> Click here to choose your specialties.

Other articles in Psychiatry >> Click here to see the complete list Genetic and environmental influences on focal brain density in bipolar disorder Brain, 09/29/10 Bipolar disorder and metabolic syndrome: An international perspective Journal of Affective Disorders, 10/07/10 Impairment of verbal learning and memory and executive function in unaffected siblings of probands with bipolar disorder Bipolar Disorders, 10/01/10

 

 

 

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The Role of Ondansetron in the Treatment of Schizophrenia (>> click to go to the journal's website)
Annals of Pharmacotherapy, 06/04/10

Bennett AC et al. – Ondansetron may be effective as an adjunct to antipsychotics for the treatment of schizophrenia, specifically negative symptoms, as assessed with PANSS. Due to the variation in concurrent therapies and dosing regimens, it is difficult to establish an optimal dose from the reviewed trials. Further large, randomized, double–blind, active–controlled studies would be helpful in determining the role of ondansetron in the treatment of schizophrenia. Receive more summaries like this by joining MDLinx. We provide free daily digests of top journal articles in your field. >> Click here to choose your specialties.

Other articles in Psychiatry >> Click here to see the complete list Examining the course and outcome of individuals diagnosed with schizophrenia and comorbid borderline personality disorder Schizophrenia Research, 10/07/10 Analysis of HapMap tag-SNPs in dysbindin (DTNBP1) reveals evidence of consistent association with schizophrenia European Psychiatry , 10/07/10 Suicidal attempts and increased right amygdala volume in schizophrenia Schizophrenia Research, 10/07/10

 

 

 

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Treatment with antipsychotics and the risk of diabetes in clinical practice (>> click to go to the journal's website)
British Journal of Psychiatry, 10/06/10

Kessing LV et al. ? The objective of this study was to investigate and characterise the incidence of diabetes for people treated with antipsychotic medication in clinical practice. In clinical practice, treatment with first- and second-generation antipsychotics is associated with an increased risk of developing incident diabetes with large differences between individual drugs. The risk increases with the duration of treatment and with polypharmacy of antipsychotic drugs. Methods Used linkage of registers of all prescribed antipsychotics, antidiabetics and diagnoses of diabetes in Denmark during period from 1996 to 2005 and identified all people treated with antipsychotics in Denmark and random sample of about 30% of total Danish population Results 345,937 patients who purchased antipsychotics and 1,426,488 unexposed individuals included 50,379 individuals subsequently developed incident diabetes Compared with unexposed individuals, treatment with first- (rate ratio, RR = 1.53, 95% CI 1.49?1.56) as well as second-generation (RR = 1.32, 95% CI 1.22?1.42) antipsychotics associated with increased risk of subsequent incident diabetes Rate of incident diabetes varied substantially between individual second-generation antipsychotic drugs (olanzapine, risperidone clozapine compared with unexposed individuals: low to moderate rate ratio between 1.17 and 1.57; ziprasidone and sertindol: 2 or more times increased rate ratio; amisulpride, quetiapine and aripiprazole: no significantly increased rate ratio) For both first- and second-generation antipsychotics, incidence of diabetes increased with number of prescriptions Incidence of diabetes increased with number of combined antipsychotic drugs Receive more summaries like this by joining MDLinx. We provide free daily digests of top journal articles in your field. >> Click here to choose your specialties.

Other articles in Psychiatry >> Click here to see the complete list Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in model behavioral models of anxiolytic and antipsychotic activity Molecular Pharmacology, 10/14/10 Psychotropic medication use mediates the relationship between mood and anxiety disorders and obesity: Findings from a nationally representative sample Journal of Psychiatric Research, 11/05/10 Risk of Hospitalization for Stroke Associated with Antipsychotic Use in the Elderly: A Self-Controlled Case Series Drugs & Aging, 11/05/10

 

 

 

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The Clinical Course of Advanced Dementia (>> click to go to the journal's website)
New England Journal of Medicine, 10/16/09

Mitchell SL et al. – Pneumonia, febrile episodes, and eating problems are frequent complications in patients with advanced dementia, and these complications are associated with high 6–month mortality rates. Distressing symptoms and burdensome interventions are also common among such patients. Patients with health care proxies who have an understanding of the prognosis and clinical course are likely to receive less aggressive care near the end of life. Receive more summaries like this by joining MDLinx. We provide free daily digests of top journal articles in your field. >> Click here to choose your specialties.

Other articles in Internal Medicine >> Click here to see the complete list Focus on dementia EurekAlert, 10/18/10 Anticholinergic drug use and risk for dementia: target for dementia prevention European Archives of Psychiatry and Clinical Neuroscience, 11/03/10 High normal fasting blood glucose is associated with dementia in Chinese elderly Alzheimer's & Dementia , 11/03/10

 

 

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The relational turn in psychoanalysis: revolution or regression (>> click to go to the journal's website)
European Journal of Psychotherapy, Counselling & Health, 11/03/10

Carmeli Z et al. – The authors discuss the Relational turn in psychoanalysis that has supposedly taken place in the course of the past 25 years. They spell out the foundational claims of the Relational group and its view that it has revolutionized psychoanalysis by bringing its relational potential to fruition. After clarifying these Relational views, the authors explain why they think that the change introduced is misguided and not as revolutionary as it appears. The authors argue that counter to its self–perception, the relational group in fact reverts to a pre–analytic conception of the person and to an authoritarian stance in relation to the patient. Receive more summaries like this by joining MDLinx. We provide free daily digests of top journal articles in your field. >> Click here to choose your specialties.

Other articles in Psychiatry >> Click here to see the complete list

 

 

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Predictors of switching antipsychotic medications in the treatment of schizophrenia (>> click to go to the journal's website)
BMC Psychiatry, 10/06/10

Nyhuis AW et al. – Switching antipsychotics appears to be prevalent in the naturalistic treatment of schizophrenia and can be predicted by a small and distinct set of variables. Interestingly, worsening of anxiety and depressive symptoms and of akathisia following 2 weeks of treatment were among the more robust predictors of subsequent switching of antipsychotics. Receive more summaries like this by joining MDLinx. We provide free daily digests of top journal articles in your field. >> Click here to choose your specialties.

Other articles in Psychiatry >> Click here to see the complete list Gabapentin adjunctive to risperidone or olanzapine in partially responsive schizophrenia: an open-label pilot study Neuropsychiatric Disease and Treatment, 11/02/10 Comparative mortality associated with ziprasidone and olanzapine in real-world use among 18,154 patients with schizophrenia: The ziprasidone observational study of cardiac outcomes (zodiac) American Journal of Psychiatry, 11/03/10 Incidence and Costs of Cardiometabolic Conditions in Patients with Schizophrenia Treated with Antipsychotic Medications Clinical Schizophrenia & Related Psychoses, 11/02/10

 

 

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Topiramate for the Treatment of Alcohol Dependence: Comparison with Naltrexone (>> click to go to the journal's website)
European Addiction Research, 10/28/10

Florez G et al. – Topiramate at a mean dose of 200 mg/day was better than naltrexone at a mean dose of 50 mg/day at reducing alcohol intake and cravings throughout the study. Receive more summaries like this by joining MDLinx. We provide free daily digests of top journal articles in your field. >> Click here to choose your specialties.

Other articles in Psychiatry >> Click here to see the complete list An Assessment of the Demographic and Clinical Correlates of the Dimensions of Alcohol Use Behaviour Alcohol and Alcoholism , 09/30/10 Discrepancy between how children perceive their own alcohol risk and how they perceive alcohol risk for other children longitudinally predicts alcohol use Addictive Behaviours, 10/04/10 Increase in Alcohol Intake, Reduced Flexibility of Alcohol Drinking, and Evidence of Signs of Alcohol Intoxication in Sardinian Alcohol-Preferring model Exposed to Intermittent Access to 20% Alcohol Alcoholism, 09/29/10