MDLinx - UpToDate

Evolution of gastro-oesophageal reflux disease over 5 years under routine medical care ? the ProGERD study Alimentary Pharmacology and Therapeutics, 11/10/11 Malfertheiner P et al. – A total of 6215 patients were enrolled in the study of whom 2721 patients completed the 5–year follow–up. Progression, regression and stability of gastro–oesophageal reflux disease(GERD) severity were followed from baseline to 5 years. Most GERD patients remain stable or improve over a 5–year observation period under current routine clinical care.       Role of bisphosphonates in the management of postmenopausal osteoporosis: an update on recent safety anxieties Menopause International, 09/09/11

Hollick RJ et al. – This review summarizes the benefits and potential adverse effects of bisphosphonates used in the treatment of postmenopausal osteoporosis. Although evidence of a definitive casual relationship between bisphosphonate therapy and serious adverse effects is lacking, concern remains particularly in relation to atypical subtrochanteric and femoral shaft fractures. This has important consequences in terms of determining optimum duration of therapy and how best to target therapy at those most at risk. Recently, attention has focused on individual fracture risk assessment in order to optimize the risk?benefit ratio of treatment for individual patients. A review of the role of hormone replacement therapy in younger women with significant risk of osteoporotic fractures may be timely in these circumstances.