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MDLinx  Psychiatry 5 minutes to stay current Your Article Summary Antipsychotic medication-induced dysphoria: Its meaning, association with typical vs. atypical medications and impact on adherence Psychiatric Quarterly, 09/12/14 Emily Wu H, et al. – There is some evidence that dopamine blockade maybe involved in the pathogenesis of antipsychotic medication-induced dysphoria. However, the limited methods of the currently available studies make it impossible to conclusively address the question of which class of antipsychotic (first- or second-generation) has a higher prevalence and severity of the syndrome. Antipsychotic medication-induced dysphoria is a relatively under-recognized and understudied effect of antipsychotic medication. Although the term is encountered in clinical practice and in the literature, there is no consensus regarding its exact meaning. This article is a narrative review of the literature on antipsychotic medication and dysphoria based on a pubmed database search. The authors found that antipsychotic medication-induced dysphoria is a term used to describe a negative and unpleasant affective state which seems to be more often associated with high potency first-generation antipsychotics and could potentially lead to medication non-adherence. Though it is plausible to expect antipsychotic medication-induced dysphoria to be related to extrapyramidal symptoms, most especially akathisia, the nature of the association remains unspecified. Receive more summaries like this by joining MDLinx. We provide free daily digests of top journal articles in your field. >> Click here to choose your specialties. Other articles in Psychiatry >> Click here to see the complete list Young adult psychological outcome after puberty suppression and gender reassignment Pediatrics, 09/12/14 Rectal lactobacillus species and their influence on the vaginal microflora: A model of male-to-female transsexual women The Journal of Sexual Medicine, 09/10/14 Association Study of ERβ, AR, and CYP19A1 Genes and MtF Transsexualism The Journal of Sexual Medicine, 09/05/14