Aripiprazole as an Adjunct to Clozapine Therapy in
Adolescents with Early-onset Schizophrenia: A Retrospective Chart Review
Pharmacopsychiatry, 07/09/09
Bachmann CJ et al. - In adolescents with schizophrenia, aripiprazole augmentation of clozapine treatment might be an effective therapeutic strategy. Prospective studies for this age group are required to obtain more specific clinical data on clinical effectiveness.
Methods- We included 15 patients with schizophrenia from a child and adolescent psychiatric department (8 male; mean age 19.3 [SD±1.2, range 17.2-21.2] years).
- Patients had been under clozapine treatment, followed by aripiprazole augmentation.
- Retrospectively, patients' medical records were reviewed, using a rating scale in analogy to the Clinical Global Impressions (CGI) scale.
- Mean observation time was 11.1 [SD±9.7] months.
- Mean CGI-Severity scores improved significantly (p=0.003, d=0.76) from 5.3 (baseline) to 4.5 (endpoint; last observation carried forward (LOCF)).
- CGI-Improvement scores decreased from 3.7 (after 1 month) to 3.3 (endpoint; LOCF) (p=0.212, d=0.45).
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