modafinila in ADHD

  • Kahbazi M et al. – The results of this study indicate that modafinil significantly improved symptoms of ADHD, was well tolerated, and may open a new window in the treatment of children with ADHD.
Methods
  • Patients were 46 outpatients, children (35 boys and 11 girls) between the ages of 6 and 15 who clearly met the DSM–IV–TR diagnostic criteria for ADHD.
  • All study subjects were randomly assigned to receive treatment with modafinil in a film–coated tablet, 200–300 mg/day, depending on weight (200 mg/day for <30 kg and 300 mg/day for >30 kg) (group 1) or placebo (group 2) for a 6–week double–blind, randomized clinical trial.
  • The principal outcome measure was the Teacher and Parent ADHD Rating Scale–IV.
  • Patients were assessed by a psychiatrist at baseline, 14, 28 and 42 days after the medication started.
Results
  • At 6 weeks, modafinil produced a significantly better outcome on the Parent and Teacher Rating Scale scores than placebo.
  • Decreased appetite was observed more often in the modafinil group.

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