Tardive dyskinesia in a patient treated with quetiapine

Tardive dyskinesia in a patient treated with quetiapine
World Journal of Biological Psychiatry, 03/04/09

Rizos E et al. - Quetiapine is an atypical antipsychotic that is believed to have a low D2 binding affinity in striatal and extrastriatal regions. Although, it is under consideration the possibility that the improvement could have been due to the discontinuation of quetiapine, the authors conclude that aripiprazole improved the TD symptom

 

 

 

Differential efficacy of escitalopram and nortriptyline on dimensional measures of depression
British Journal of Psychiatry, 03/04/0

Uher R et al. - Mixed-effect linear regression showed no difference between escitalopram and nortriptyline on the three original scales, but symptom dimensions revealed drug-specific advantages. Observed mood and cognitive symptoms improved more with escitalopram than with nortriptyline. Neurovegetative symptoms improved more with nortriptyline than with escitalopram

 

 

 

Unmet Need for Treatment of Major Depression in the United States
Psychiatric Services, 03/03/09

Mojtabai R. - Many persons with major depression continue to experience unmet need for treatment, which in this study was mainly attributable to concerns about treatment costs. Methods

• Sample of 6,510 adult participants in the 2005 and 2006 National Surveys on Drug Use and Health who reported a major depressive episode in the past 12 months.
• Participants who sought mental health treatment in the past 12 months.
• Participants had not sought mental health treatment in the past 12 months.

Results

• 3,568 (62.4%) participants had sought mental health treatment in the past 12 months
• 2,942 (37.6%) had not.
• 34.9% and 26.8% of these groups, respectively, reported unmet need for treatment.
• Older age was associated with a lower likelihood of reporting unmet need for treatment.
• li> Greater distress and impairment and higher education were associated with a greater likelihood of reporting unmet need.
• Treatment from general medical providers was associated with greater likelihood of unmet need.
• More outpatient visits and insurance coverage for the full year were associated with a lower likelihood of unmet need.
• Most common reason for not seeking needed treatment was a concern about costs.

 

 

 

Panic symptoms in schizophrenia: Comorbidity and clinical correlates
Psychiatry and Clinical Neurosciences, 03/03/09

Ulas H et al. - Patients with panic symptoms had higher scores of PANSS, HDRS, CGI and ESRS. Comorbid panic symptoms in schizophrenia may be related to positive symptoms, extrapyramidal side-effects and depression.