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Your Article Summary  Antidepressants for depression in patients with dementia: A review of literature The Consultant Pharmacist, 04/08/14 Leong C, et al. – The study aims to evaluate the literature investigating the efficacy and safety of antidepressants for treating depression in individuals with dementia. The evidence for antidepressants in the treatment of depression in patients with dementia is inconclusive. The accumulation of evidence suggests nonpharmacologic approaches and watchful waiting be attempted for the first 8 to 12 weeks in a patient who presents with both mild–to–moderate depression and dementia. In cases of severe depression, or depression not managed through nonpharmacologic means, a trial of an antidepressant may be initiated.

    Antidepressant-induced liver injury: a review for clinicians
   American Journal of Psychiatry, 04/08/14

Voican CS, et al. – The authors review clinical data relevant to antidepressant–induced liver injury and provide recommendations for clinical practice. Although an infrequent event, DILI from antidepressant drugs may be irreversible, and clinicians should be aware of it. Aminotransferase surveillance is the most useful tool for detecting DILI, and prompt discontinuation of the drug responsible is essential. The results of antidepressant liver toxicity in all phases of clinical trials should be available and published. Further research is needed before any new and rigorously founded recommendations can be made.

Affective disorders and risk of developing dementia: systematic review
The British Journal of Psychiatry, 03/04/13

da Silva J et al. - The study aims to evaluate the risk of developing dementia in individuals with a history of affective disorder. Affective disorders appear to be associated with an increased risk of developing dementia, and one that is dependent on clinical and demographic variables. Depression may be both a prodrome and a risk factor for dementia. 

Selective serotonin reuptake inhibitor drug interactions in patients receiving statins
The Journal of Clinical Psychiatry, 03/05/14
Andrade C – Elderly patients commonly receive statin drugs for the primary or secondary prevention of cardiovascular and cerebrovascular events. Elderly patients also commonly receive antidepressant drugs, usually selective serotonin reuptake inhibitors (SSRIs), for the treatment of depression, anxiety, or other conditions. SSRIs are associated with many pharmacokinetic drug interactions related to the inhibition of the cytochrome P450 (CYP) metabolic pathways.

Metabolic Syndrome and Metabolic Abnormalities in Bipolar Disorder: A Meta-Analysis of Prevalence Rates and Moderators
American Journal of Psychiatry, 03/04/13
Vancampfort D et al. – The authors sought to clarify the prevalence and moderators of metabolic syndrome in bipolar patients, accounting for subgroup differences. The findings strongly support the claim that patients with bipolar disorder are at high risk for metabolic syndrome and related cardiovascular morbidity and mortality and require regular monitoring and adequate preventive efforts and treatment for cardio–metabolic risk factors. These findings further suggest that the risk of metabolic syndrome is greater in bipolar patients taking prescribed antipsychotic medication.

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Long-term use of valproic acid in US veterans is associated with a reduced risk of smoking-related cases of head and neck cancer
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