Stojanovic OI et al. – The latest data support the correlation of atherosclerosis and osteoporosis, indicating the parallel progression of two
tissue destruction processes
with increased fatal and non–fatal coronary events, as well as higher fracture risk.
Vitamin D inadequacy associated with low bone mineral density increases fall and fracture risk, leads to secondary hyperparathyroidism, calcifies
coronary arteries and
significantly increases cardiovascular disease.
Randomized clinical trial evidence related to extraskeletal vitamin D outcomes was limited and generally uninformative.
A recent recommendation on vitamin D dietary requirements for bone health is 600 IU/d for ages 1–70 years and 800 IU/d for 71 years and
older, corresponding to a serum
25–hydroxyvitamin D level of at least 20 ng/ml (50 nmol/l)
Further large randomized controlled trials are needed to reassess laboratory ranges for 25–hydroxyvitamin D in both diseases, in order to
avoid under– and
over–treatment problems, and completely clarify the relationship between atherosclerosis and osteoporosis.
Raju N et al. – Aspirin prevents deaths, myocardial infarction, and ischemic stroke, and increases hemorrhagic stroke and major bleeding when
used in the primary prevention
of cardiovascular disease. Methods
Eligible articles were identified by searches of electronic databases and reference lists.
Outcomes of interest were all–cause mortality, cardiovascular mortality, myocardial infarction, stroke, and bleeding.
Data were pooled from individual trials using the DerSimonian–Laird random–effects model, and results are presented as relative risk
(RR) and 95% confidence
Nine randomized controlled trials enrolling 100,076 participants were included.
Aspirin reduced all–cause mortality (RR 0.94; 95% CI, 0.88–1.00), myocardial infarction (RR 0.83; 95% CI, 0.69–1.00), ischemic
stroke (RR 0.86; 95% CI,
0.75–0.98), and the composite of myocardial infarction, stroke, or cardiovascular death (RR 0.88; 95% CI, 0.83–0.94), but did not reduce
cardiovascular mortality (RR
0.96; 95% CI, 0.84–1.09).
Aspirin increased the risk of hemorrhagic stroke (RR 1.36; 95% CI, 1.01–1.82), major bleeding (RR 1.66; 95% CI, 1.41–1.95), and
gastrointestinal bleeding (RR
1.37; 95% CI, 1.15–1.62).
A lack of availability of patient–level data precluded exploration of benefits and risks of aspirin in key subgroups.
Istoric In Romania, in vremea comunismului, pshiatrii au fost incadrati in APR, ramura a celorlalte ramuri medicale.Dupa 1989 APR si-a coninuat prezenta, fiind in continuare condusa de urmasii lui Predescu, Gorgos, Angheluta & co. APR se face vinovat in fata istoriei printr-o selectie mafiotica care a coborit psihiatria romaneasca la un instrument de persecutie a regimului fata deorice aspiratie de innoire,de respingerea a numeroase valori care n-au incaput in breasla si au trebuit sa emigreze sau sa fie marginalizati, perspectiveneavind decit cei hiperadaptati la teroarea raului. Persecutiile fata de psihiatrii si chiar fata de unii bolnavi sunt cunoscute. Text integral