Anomaliile dezvoltarii creerului schizofrenic

Schizophrenia delays and alters maturation of the brain in adolescence
Brain,

Douaud G et al. – Results suggest common etiological mechanisms for adolescent- and adult-onset schizophrenia with an altered neurodevelopmental time course in the schizophrenic pt that is particularly salient in adolescence.

Methods

• Study of whether a striking sensorimotor-related pattern is an artefact due to better sensitivity of methods or whether apparent greater structural abnormalities in early-onset population are specifically associated with earlier disease onset
• For a characteristic structural pattern, investigation of whether these anatomical abnormalities remain static or, conversely, show dynamic changes in still-developing brain
• Combination of a cross-sectional study of brain structure for 25 adolescent-onset pts and 35 adult-onset patients and respective matched healthy subjects with a longitudinal study of 12 adolescent-onset pts representative subset ofcross-sectional group) and matched healthy controls for >2 yrs
• Investigation of differences between adolescent and adult pt grey matter volume and white matter microstructure abnormalities

Results

• Confirmation of specificity (especially in motor-related areas) and greater severity of structural abnormalities in adolescent pts
• On closer examination greater anomalies may arise because the developmental time course differ for adolescent pts vs healthy controls
• Longitudinal analysis of a representative subset of the adolescent pt and matched healthy populations corroborated the delayed and altered maturation in both grey and white matters
• Structural abnormalities specific to adolescent-onset schizophrenia in sensori-motor cortices and corticospinal tract less marked or even disappeared with longitudinal observation
• Grey matter abnormalities in adolescent pts evolved towards the adult-onset pattern as defined by recent meta-analyses of adult schizophrenia