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MDLinx  Psychiatry 5 minutes to stay current Your Article Summary Efficacy of atomoxetine in adults with attention deficit hyperactivity disorder: An integrated analysis of the complete database of multicenter placebo-controlled trials Journal of Psychopharmacology, 07/31/14 Asherson P, et al. – In this study, authors found that ATX had a clinically significant effect in adults with ADHD, with reductions in core symptoms and clinically meaningful responder rates. Methods They performed an integrated analysis of all Eli Lilly–sponsored, randomized, double–blind, placebo–controlled studies of ATX in adults with ADHD completed as of May 2012. Individual patient data were pooled from six short–term (10–16 week) studies (1961 patients) and three longer–term (six–month) studies (1413 patients). Results In the short–term analysis, ATX patients achieved a significantly greater mean reduction in ADHD symptoms than placebo patients (–12.2 vs –8.1; Conners' Adult ADHD Rating Scale–Investigator–Rated: Screening Version (CAARS–Inv: SV); p<0 data-blogger-escaped-.001="" data-blogger-escaped-li=""> In the longer–term analysis, respective improvements after six months were –13.2 vs –9.7 (p<0 data-blogger-escaped-.001="" data-blogger-escaped-li=""> Response rates at study endpoints for ATX vs placebo, based on CAARS–Inv: SV improvement ≥30% and Clinical Global Impressions of ADHD–Severity (CGI–ADHD–S) ≤3 were 34.8% vs 22.3% in the short–term and 43.4% vs 28.0% after six months, and CAARS–Inv: SV improvements ≥40% were 41.3% vs 25.3% in the short–term and 44.0% vs 31.4% after six months (all p<0 data-blogger-escaped-.001="" data-blogger-escaped-li=""> Receive more summaries like this by joining MDLinx. We provide free daily digests of top journal articles in your field. >> Click here to choose your specialties. Other articles in Psychiatry >> Click here to see the complete list Time elapsed after ischemic stroke and risk of adverse cardiovascular events and mortality following elective noncardiac surgery JAMA, 07/17/14 Cardiac autonomic dysfunction and arterial stiffness among children and adolescents with attention deficit hyperactivity disorder treated with stimulants The Journal of Pediatrics, 07/15/14