Sahraian A, et al. – The authors examined whether obsessive compulsive symptoms in patients with bipolar disorder respond to topiramate as an adjuvant treatment. They found that the combination of lithium+olanzapine+clonazepam decreased the symptoms of obsessive compulsive disorder in the patients with bipolar disorder type I. However, topiramate had a more significant effect than placebo on improvement of the patients with bipolar disorder and obsessive compulsive symptoms. This combination seems to be without serious adverse effects. Methods
This 4–month double–blind placebo–controlled randomized clinical trial examined the efficacy and safety of augmentation with topiramat for treating the patients with bipolar disorder, manic phase type–I, and obsessive compulsive disorder symptoms.
Both groups received lithium+olanzapine+clonazepam.
However, one group received topiramate and the other group placebo as adjuvant medications.
Yale Brown obsessive compulsive behavior scale was used to assess the outcome.
Adverse effects were also recorded.
A total of 32 patients completed this trial.
The mean score decreased from 24.2(4.8) to 17.6(8.7) in the topiramate group (P<0 data-blogger-escaped-.003="" data-blogger-escaped-20.9="" data-blogger-escaped-9.6="" data-blogger-escaped-and="" data-blogger-escaped-during="" data-blogger-escaped-from="" data-blogger-escaped-group="" data-blogger-escaped-in="" data-blogger-escaped-li="" data-blogger-escaped-placebo="" data-blogger-escaped-the="" data-blogger-escaped-this="" data-blogger-escaped-to="" data-blogger-escaped-trial="">
Additionally, 9(52.9%) out of 17 patients in the topiramate group and 2(12.5%) out of 16 patients in the placebo group showed more than 34% decline in YBOC score (x2=6.0, df=1, P<0 data-blogger-escaped-.01="" data-blogger-escaped-li="">
Istoric In Romania, in vremea comunismului, pshiatrii au fost incadrati in APR, ramura a celorlalte ramuri medicale.Dupa 1989 APR si-a coninuat prezenta, fiind in continuare condusa de urmasii lui Predescu, Gorgos, Angheluta & co. APR se face vinovat in fata istoriei printr-o selectie mafiotica care a coborit psihiatria romaneasca la un instrument de persecutie a regimului fata deorice aspiratie de innoire,de respingerea a numeroase valori care n-au incaput in breasla si au trebuit sa emigreze sau sa fie marginalizati, perspectiveneavind decit cei hiperadaptati la teroarea raului. Persecutiile fata de psihiatrii si chiar fata de unii bolnavi sunt cunoscute. Text integral